KUNITZ PANCREATIC TRYPSIN INHIBITOR
\kjˈuːnɪts pˌankɹiːˈe͡ɪtɪk tɹˈɪpsɪn ɪnhˈɪbɪtə], \kjˈuːnɪts pˌankɹiːˈeɪtɪk tɹˈɪpsɪn ɪnhˈɪbɪtə], \k_j_ˈuː_n_ɪ_t_s p_ˌa_n_k_ɹ_iː__ˈeɪ_t_ɪ_k t_ɹ_ˈɪ_p_s_ɪ_n ɪ_n_h_ˈɪ_b_ɪ_t_ə]\
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A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including chymotrypsin, kallikrein, plasmin, and trypsin. It is used in the treatment of hemorrhage associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with extracorporeal circulation. (Reynolds JEF (Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.
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