RU486
\ɹˈuː fˈɔːhˈʌndɹədən ˈe͡ɪtisˈɪks], \ɹˈuː fˈɔːhˈʌndɹədən ˈeɪtisˈɪks], \ɹ_ˈuː f_ˈɔː_h_ˈʌ_n_d_ɹ_ə_d_ə_n ˈeɪ_t_i_s_ˈɪ_k_s]\
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A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
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Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.