MEN II
\mˈɛn ɹˌə͡ʊmən tˈuː], \mˈɛn ɹˌəʊmən tˈuː], \m_ˈɛ_n ɹ_ˌəʊ_m_ə_n_ t_ˈuː]\
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A type of multiple endocrine neoplasia characterized by a virtually 100% incidence of medullary thyroid carcinoma, a 50% incidence of pheochromocytoma, and a lesser incidence of parathyroid adenomas associated with hyperparathyroidism. The condition is always transmitted through autosomal dominant inheritance. Genetic testing can identify individuals with the trait in early infancy. Treatment is usually excision of the enlarged parathyroid glands. (From Holland et al., Cancer Medicine, 3d ed, pp1172-75)
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Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.