FRANKLINS DISEASE
\fɹˈaŋklɪnz dɪzˈiːz], \fɹˈaŋklɪnz dɪzˈiːz], \f_ɹ_ˈa_ŋ_k_l_ɪ_n_z d_ɪ_z_ˈiː_z]\
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A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N- (amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.