SPINE ACHE
\spˈa͡ɪn ˈe͡ɪk], \spˈaɪn ˈeɪk], \s_p_ˈaɪ_n ˈeɪ_k]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.