OXFORD ACT
\ˈɒksfəd ˈakt], \ˈɒksfəd ˈakt], \ˈɒ_k_s_f_ə_d ˈa_k_t]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.