MEMBRANE ATTACK COMPLEX
\mˈɛmbɹe͡ɪn ɐtˈak kˈɒmplɛks], \mˈɛmbɹeɪn ɐtˈak kˈɒmplɛks], \m_ˈɛ_m_b_ɹ_eɪ_n ɐ_t_ˈa_k k_ˈɒ_m_p_l_ɛ_k_s]\
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The assembly of complement plasma glycoproteins C5b, C6, C7, C8, and polymeric C9 as a group on biological membranes. The complex forms transmembrane channels which displace lipid molecules and other constituents, thus disrupting the phospholipid bilayer of target cells leading to cell lysis by osmotic leakage. The formation of the membrane attack complex is the terminal step in the complement cascade.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.