ICI80,966

\ˈa͡ɪsa͡ɪ ˈe͡ɪti θˈa͡ʊzənd nˈa͡ɪnhˈʌndɹədən sˈɪkstisˈɪks], \ˈa‍ɪsa‍ɪ ˈe‍ɪti θˈa‍ʊzənd nˈa‍ɪnhˈʌndɹədən sˈɪkstisˈɪks], \ˈaɪ_s_aɪ ˈeɪ_t_i θ_ˈaʊ_z_ə_n_d_ n_ˈaɪ_n_h_ˈʌ_n_d_ɹ_ə_d_ə_n s_ˈɪ_k_s_t_i_s_ˈɪ_k_s]\

Definitions of ICI80,966

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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