CONTRACTURA
\kəntɹˈakt͡ʃəɹə], \kəntɹˈaktʃəɹə], \k_ə_n_t_ɹ_ˈa_k_tʃ_ə_ɹ_ə]\
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A state of permanent rigidity and progressive atrophy of the flexor muscles, which prevents the motions of extension beyond a certain limit. The affected muscles form hard cords beneath the skin. On dissection, they are found converted into tendinous fibres, the fleshy fibres having almost disappeared, when the disease has been of any duration. It succeeds, frequently, other diseases, particularly rheumatis, neuralgia, convulsions, syphilis, colica pictonum, &c. The warm bath, vapour bath, or thermal waters, oleaginous embrocations, mechanical extension of the limbs, &c., are the chief means of treatment.
By Robley Dunglison
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.