COMBINATION ANTIBIOTICS
\kˌɒmbɪnˈe͡ɪʃən ˌantɪba͡ɪˈɒtɪks], \kˌɒmbɪnˈeɪʃən ˌantɪbaɪˈɒtɪks], \k_ˌɒ_m_b_ɪ_n_ˈeɪ_ʃ_ə_n ˌa_n_t_ɪ_b_aɪ_ˈɒ_t_ɪ_k_s]\
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Combinations of antibiotics used against difficult-to-treat infections. Antibiotic combinations have been used mainly to broaden the antibacterial spectrum and prevent development of resistance. In some instances these combinations have shown lower toxicity, but drug antagonism may be one of the problems encountered by their use. They may be given simultaneously or sequentially. The drugs need not be in the same dosage form.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.