TONGUE FASCICULATION
\tˈʌŋ fˌasɪkjʊlˈe͡ɪʃən], \tˈʌŋ fˌasɪkjʊlˈeɪʃən], \t_ˈʌ_ŋ f_ˌa_s_ɪ_k_j_ʊ_l_ˈeɪ_ʃ_ə_n]\
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Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations can often by visualized and take the form of a muscle twitch or dimpling under the skin, but usually do not generate sufficient force to move a limb. They may represent a benign condition or occur as a manifestation of MOTOR NEURON DISEASE or PERIPHERAL NERVOUS SYSTEM DISEASES. (Adams et al., Principles of Neurology, 6th ed, p1294)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.