SYNTHETASE, 7,8 DIHYDRONEOPTERINTRIPHOSPHATE
\sˈɪnθɪtˌe͡ɪs], \sˈɪnθɪtˌeɪs], \s_ˈɪ_n_θ_ɪ_t_ˌeɪ_s]\
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(GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
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