PALATINE CANALS

\pˈalɐtˌiːn kənˈalz], \pˈalɐtˌiːn kənˈalz], \p_ˈa_l_ɐ_t_ˌiː_n k_ə_n_ˈa_l_z]\
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1846 - Medical lexicon: a dictionary of medical science
By Robley Dunglison

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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