MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS
\mˈɛmbɹɐnˌɒpɹəlˌɪfəɹətˌɪv ɡlˌɒməɹˌuːlə͡ʊnfɹˈa͡ɪtɪs], \mˈɛmbɹɐnˌɒpɹəlˌɪfəɹətˌɪv ɡlˌɒməɹˌuːləʊnfɹˈaɪtɪs], \m_ˈɛ_m_b_ɹ_ɐ_n_ˌɒ_p_ɹ_ə_l_ˌɪ_f_ə_ɹ_ə_t_ˌɪ_v ɡ_l_ˌɒ_m_ə_ɹ_ˌuː_l_əʊ_n_f_ɹ_ˈaɪ_t_ɪ_s]\
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Chronic glomerulonephritis characterized histologically by proliferation of mesangial cells, increase in the mesangial matrix, and a thickening of the glomerular capillary walls. The wall thickening is sometimes said to be a result of the interposition of mesangial cytoplasm or matrix between the basement membrane and the endothelium of the capillary wall. It is often divided into types I and II, and sometimes III. Pathogenesis is not well understood, but some types are thought to involve the immune system, with the complement system, in particular, being implicated.
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