HISTORICAL ARTICLE [PUBLICATION TYPE]

\hɪstˈɒɹɪkə͡l ˈɑːtɪkə͡l pˌʌblɪkˈe͡ɪʃən tˈa͡ɪp], \hɪstˈɒɹɪkə‍l ˈɑːtɪkə‍l pˌʌblɪkˈe‍ɪʃən tˈa‍ɪp], \h_ɪ_s_t_ˈɒ_ɹ_ɪ_k_əl ˈɑː_t_ɪ_k_əl__ p_ˌʌ_b_l_ɪ_k_ˈeɪ_ʃ_ə_n t_ˈaɪ_p]\

Definitions of HISTORICAL ARTICLE [PUBLICATION TYPE]

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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