EMPLATRE

\ɛmplˈatə], \ɛmplˈatə], \ɛ_m_p_l_ˈa_t_ə]\
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  • Emplastrum-e. Emplastrum de pice et resists glutinans-. e. Emplastrum cicutae-e. Emplastrum de pice et resinis glutinans-e. Emplastrum cum gummi-resinis- e. Emplastrum Norimbergense.
1846 - Medical lexicon: a dictionary of medical science
By Robley Dunglison

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  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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