CONNECTING PEPTIDE
\kənˈɛktɪŋ pˈɛpta͡ɪd], \kənˈɛktɪŋ pˈɛptaɪd], \k_ə_n_ˈɛ_k_t_ɪ_ŋ p_ˈɛ_p_t_aɪ_d]\
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A 31-amino acid peptide which connects the A and B chains of proinsulin. The exact composition of the peptide is species dependent. In beta cells proinsulin is enzymatically converted to insulin with the liberation of the C-peptide. An immunoassay has been developed for assessing pancreatic beta cell secretory function in diabetic patients in whom circulating insulin antibodies and exogenous insulin interfere with insulin immunoassay.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.