ALKALINE COMET ASSAYS
\ˈalkəlˌa͡ɪn kˈɒmɪt ɐsˈe͡ɪz], \ˈalkəlˌaɪn kˈɒmɪt ɐsˈeɪz], \ˈa_l_k_ə_l_ˌaɪ_n k_ˈɒ_m_ɪ_t ɐ_s_ˈeɪ_z]\
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A genotoxicological technique for measuring DNA damage in an individual cell using single-cell gel electrophoresis. Cell DNA fragments assume a "comet with tail" formation on electrophoresis and are detected with an image analysis system. Alkaline assay conditions facilitate sensitive detection of single-strand damage.
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.